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Flavonoid and lignan intake and pancreatic cancer risk in the European prospective investigation into cancer and nutrition cohort

Molina-Montes, Esther (author)
CIBER Epidemiology and Public Health (CIBERESP)
Sánchez, María José (author)
CIBER Epidemiology and Public Health (CIBERESP)
Zamora-Ros, Raul (author)
International Agency for Research on Cancer, World Health Organization
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Bueno-de-Mesquita, H. Bas (author)
University of Malaya
Wark, Petra A. (author)
Imperial College London
Obon-Santacana, Mireia (author)
Catalan Institute of Oncology
Kühn, Tilman (author)
German Cancer Research Centre
Katzke, Verena (author)
German Cancer Research Centre
Travis, Ruth C. (author)
University of Oxford
Ye, Weimin (author)
Karolinska Institutet,Umeå universitet,Umeå University,Enheten för biobanksforskning,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Sund, Malin (author)
Umeå universitet,Umeå University,Enheten för biobanksforskning,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Naccarati, Alessio (author)
Human Genetics Foundation (HuGeF)
Mattiello, Amalia (author)
University of Naples Federico II
Krogh, Vittorio (author)
Istituto Nazionale dei Tumori
Martorana, Caterina (author)
Civic and M.P Arezzo Hospital
Masala, Giovanna (author)
Cancer Research and Prevention Institute (ISPO)
Amiano, Pilar (author)
Biodonostia Health Research Institute
Huerta, José María (author)
Murcia Regional Health Council
Barricarte, Aurelio (author)
Health Research Institute of Navarra (IDISNA)
Quirós, José Ramón (author)
Public Health Directorate
Weiderpass, Elisabete (author)
Karolinska Institutet
Angell Åsli, Lene (author)
UiT The Arctic University of Norway, Tromsø
Skeie, Guri (author)
UiT The Arctic University of Norway, Tromsø
Ericson, Ulrika (author)
Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine
Sonestedt, Emily (author)
Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine
Peeters, Petra H. (author)
University Medical Center Utrecht
Romieu, Isabelle (author)
International Agency for Research on Cancer, World Health Organization
Scalbert, Augustin (author)
International Agency for Research on Cancer, World Health Organization
Overvad, Kim (author)
Aarhus University
Clemens, Matthias (author)
German Institute of Human Nutrition
Boeing, Heiner (author)
German Institute of Human Nutrition
Trichopoulou, Antonia (author)
National and Kapodistrian University of Athens
Peppa, Eleni (author)
Hellenic Health Foundation, Athens
Vidalis, Pavlos (author)
Hellenic Health Foundation, Athens
Khaw, Kay Tee (author)
University of Cambridge
Wareham, Nick (author)
MRC Human Nutrition Research
Olsen, Anja (author)
Danish Cancer Society
Tjønneland, Anne (author)
Danish Cancer Society
Boutroun-Rualt, Marie Christine (author)
Centre for Research in Epidemiology and Population Health (CESP)
Clavel-Chapelon, Françoise (author)
Centre for Research in Epidemiology and Population Health (CESP)
Cross, Amanda J. (author)
Imperial College London
Lu, Yunxia (author)
Imperial College London
Riboli, Elio (author)
Imperial College London
Duell, Eric J. (author)
Catalan Institute of Oncology
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 (creator_code:org_t)
2016-06-10
2016
English 13 s.
In: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 139:7, s. 1480-1492
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Despite the potential cancer preventive effects of flavonoids and lignans, their ability to reduce pancreatic cancer risk has not been demonstrated in epidemiological studies. Our aim was to examine the association between dietary intakes of flavonoids and lignans and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 865 exocrine pancreatic cancer cases occurred after 11.3 years of follow-up of 477,309 cohort members. Dietary flavonoid and lignan intake was estimated through validated dietary questionnaires and the US Department of Agriculture (USDA) and Phenol Explorer databases. Hazard ratios (HR) and 95% confidence intervals (CIs) were calculated using age, sex and center-stratified Cox proportional hazards models, adjusted for energy intake, body mass index (BMI), smoking, alcohol and diabetes status. Our results showed that neither overall dietary intake of flavonoids nor of lignans were associated with pancreatic cancer risk (multivariable-adjusted HR for a doubling of intake = 1.03, 95% CI: 0.95–1.11 and 1.02; 95% CI: 0.89–1.17, respectively). Statistically significant associations were also not observed by flavonoid subclasses. An inverse association between intake of flavanones and pancreatic cancer risk was apparent, without reaching statistical significance, in microscopically confirmed cases (HR for a doubling of intake = 0.96, 95% CI: 0.91–1.00). In conclusion, we did not observe an association between intake of flavonoids, flavonoid subclasses or lignans and pancreatic cancer risk in the EPIC cohort.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)

Keyword

cohort
diet
flavonoids
lignans
pancreatic cancer
diet

Publication and Content Type

art (subject category)
ref (subject category)

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